Author(s) :

VINAYSHRI SANDEEP TUNGIKAR .

Volume/Issue :

Abstract :

Liposomes are spherical vesicles that contain one or more phospholipids bilayers. Today they are highly useful replicas, reagents and tools in various scientific fields, including mathematics, theoretical physics, biophysics, chemistry, colloid science, biochemistry and biology. Numerous clinical studies have demonstrated the superiority of liposomal formulations over conventional delivery systems. Liposomes are the hallmark of advanced technology. Liposome research has progressed from conventional vesicles to'second generation liposomes,' which produce long-circulating liposomes by varying the lipid composition, size, and charge of the vesicles. Surface-modified liposomes have also been created by combining several molecules, including glycolipids and sialic acids. The antineoplastic agents doxorubicin, daunorubicin and cytarabine are in advanced stages of human clinical trials. One or more of these should prove to be medically useful and commercially viable products in the years to come. This white paper summarizes only the scalable approach and focuses on advantages/limitations related to industrial applicability and regulatory requirements for liposomal formulations based on FDA and EMEA documents.

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44