Author(s) :

Dr. Yuvraj R. Girbane, Dr. Gajanan A. Vaishnav.

Volume/Issue :

Abstract :

The synthesis of organic molecules using microwaves offers a range of advantages over traditional methods, such as shorter reaction times and higher yields. Quality by design (QbD) is a systematic approach to the optimization of synthetic routes and procedures that seeks to ensure the quality of the final product. QbD can lead to significant improvements in product quality, process understanding and productivity. The microwave organic synthesis is a relatively new field, but there are still many challenges associated with quality by design. One of the main challenges is to ensure that the desired product is obtained in a reproducible manner. Another is to optimize the reaction conditions to minimize sideproducts and maximize yield. This can be a time-consuming and difficult process, especially if the reaction is not well understood. Quality by Design (QbD) is a systematic approach to pharmaceutical development that focuses on designing and controlling the process. QbD can be applied to microwaveinduced organic synthesis by first identifying the critical quality attributes (CQAs) of the product, such as purity, yield, and stability. Next, the critical process parameters (CPPs) are identified and controlled through design of experiments (DOE) and process analytical technology (PAT) tools. Finally, process controls and monitoring systems are implemented to ensure that the process remains in a state of control and consistently produces the desired product quality.

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