Author(s) :

Abhay Shripad Joshi, Dr. S. S.Angadi, Dr. Gajanan A.Vaishnav, Dr. Yuvraj R. Girbane, Renuka B. Dhakne.

Volume/Issue :

Abstract :

In an open randomized crossover study, the pharmacokinetic of erythromycin were compaired with Neostigmine,Atropine,Metoclopramide and omeprazole after a single dose in 12 Wistar rats for oral and IV pharmacokinetic study.Erythromycin was administered at a dose of 50 mg/kg while other drugs Neostigmine (40 µg/kg),Atropine (10 mg/kg),Metoclopramide (12.5 mg/kg) and omeprazole (50 mg/kg) were given and oral pharmacokinetic and IV pharmacokinetic was studied. Erythromycin in combination with Omeprazole shown significant increase in Cmax (2.76 ±0.15) and AUC (7.29 ± 0.554) when given orally as compare to control group.Whereas Erythromycin in combination with Neostigmine (1.24 ± 0.755),Atropine(0.56 ± 0.085),Metoclopramide(1.06 ± 0.25) were shown less significant results. In the present study the effect of erythromycin on pharmacokinetic parameters was performed.

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