| 1 |
Author(s):
Prashant Appasaheb Rode , Ajay Jagannath Malode .
Page No : 1-11
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A Review: On Sublingual Tablet
Abstract
Sublingual administration is usually preferred when a more rapid onset
of action is required than orally-taken tablets. Sublingual tablets
provide rapid release of drug from the formulation, bypassing drug
metabolism in the liver and entering the systemic circulation directly.
Demand for rapidly disintegrating sublingual tablets has increased over
the past decade, especially for elderly and paediatric patients with
swallowing difficulties. Drug delivery systems are becoming
increasingly complex as pharmaceutical scientists better understand the
physicochemical and biochemical parameters associated with their
performance. Various techniques can be used to formulate sublingual
tablets. i.e., Direct compression, freeze-drying, etc. Sublingual tablets
require faster disintegration. Therefore, explosives should be
prescribed. i.e., It is a super disintegrant that is effective at low
concentrations and has high disintegration efficiency. Tablets were
evaluated for weight change, hardness, friability, wetting time, water
absorption, disintegration time, and dissolution studies. This review
focuses on different sublingual dosage forms, factors affecting
sublingual absorption, benefits, various in vitro and in vivo evaluation
parameters, and commercially available sublingual dosage forms.
| 2 |
Author(s):
Ajay Jagannath Malode , Prashant Appasaheb Rode.
Page No : 12-26
|
MOUTH DISSOLVING TABLETS: AN OVERVIEW
Abstract
A mouth dissolving tablet is a solid dosage form containing an active ingredient
that dissolves within one minute in the oral cavity. Convenience of administration
and improved patient compliance are important in the design of oral drug delivery
systems, and oral drug delivery systems remain the preferred route of drug
delivery despite various drawbacks. Such problems can be solved by prescribing
“Mouth dissolving tablets” (MDT) that disintegrate or rapidly dissolve in the
mouth without water within seconds due to the action of super-disintegrants, or
by changing the pore structure of the oral cavity. can be solved in new drug
delivery systems by maximizing pharmaceutical formulation. These dosage
forms are placed in the mouth and dispersed or dissolved in saliva. There is no
need for water during administration as the drug is released immediately upon
contact with saliva. The purpose of this article is to review technological
developments and advances in superdisintegrants in the formulation,
manufacturing and evaluation of these tablets. This article also describes a new
evaluation method for these orally disintegrating tablets. Various modifications
in conventional evaluation and the use of specialized equipment have proven
essential to testing these dosage forms. This review describes formulation
techniques and different techniques.
| 3 |
Author(s):
Onkar G. Bodkhe , Ajay J. Malode.
Page No : 27-35
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FAST DISSOLVING ORAL FILM: A REVIEW
Abstract
In the late Nineteen century, rapidly disintegrating drug delivery systems were developed as an alternative to capsules, tablets, and syrups for geriatric and pediatric patients with dysphagia. To meet these needs, many orally disintegrating tablets have been commercialized that disintegrate in the mouth within a minute without chewing or drinking water. Oral drug delivery technology has since been upgraded from conventional dosage forms to modified-release dosage forms, and more recently, rapidly disintegrating films have been developed instead of orally disintegrating tablets. Orally dissolving fast-dissolving films (OFDFs) have recently entered the market because they are more convenient and easier to use compared to other dosage forms such as orally disintegrating tablets. The technology has evolved in recent years from the confectionery and oral care market in the form of breath strips to become a novel form that is widely accepted by consumers, attracting a large number of pharmaceutical industry interest in his OFDF. A rapidly dissolving film in the mouth is a type of drug delivery system that disintegrates or dissolves within seconds without absorbing water when placed in the oral cavity. OFDF is very similar in shape, size and thickness to a postage stamp. These films have the ability to deliver drugs systemically via intragastric, sublingual, or buccal routes of administration and are also used for topical effect. This type of technology provides a convenient way to administer medications to the general population as well as special populations such as children, the elderly, bedridden patients, and psychiatric patients. Some companies have introduced a more robust form of fast-dissolving drug delivery that places a film on or under the tongue. When this film is applied to the tongue, it immediately dissolves and releases the drug, which dissolves in saliva. Some drugs are absorbed through the mouth, throat, and esophagus when saliva enters the stomach. In such cases, the bioavailability of the drug is improved, the risk of choking is eliminated, and the mouthfeel is improved. The current review describes various formulation considerations, manufacturing processes, and quality control of OFDF.
| 4 |
Author(s):
Anisha.L.Pradhan, Onkar .G.Bodkhe.
Page No : 36-44
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REVIEW ON MINI TABLET
Abstract
The goal of controlled drug delivery systems is to reduce dosing frequency and increase drug
efficacy. Multiple unit dosage forms (MUDF) such as pellets, granules and mini-tablets are the
most common in oral controlled drug delivery systems compared to single unit dosage forms
(SUDF). This is because we can control drug release and provide solutions. to current issues in
the pharmaceutical industry. Mini-tablets offer many advantages such as providing precise
dosages and being relatively easy to manufacture. No solvents are required for manufacturing,
which helps maintain product stability and allows great flexibility during formulation and
development. The mini-tablets are easy to swallow, so children and the elderly will appreciate them. Mini-tablets are an effective alternative to unit dosage forms. Dose dumping and local irritation can be avoided by using mini-tablets. This review focuses on different aspects of the mini tablet. They can also be filled into capsules like other multiple unit dosage forms. Therefore, it resembles a good alternative to pellets and granules. Within this framework, there have beensome major advances in recent times. This overview describes the various benefits of
minitablets, types, manufacturing processes, formulation options, and common evaluation tests for minitablets.
| 5 |
Author(s):
Aditya Kalyan Mhaske .
Page No : 45-58
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REVIEW ON ETHOSOMES
Abstract
Transdermal medication delivery refers to self-contained, discrete dosage forms that, when
applied to undamaged skin, release the drug to the systemic circulation through the skin at a
controlled rate. Ethosomes are noninvasive drug delivery systems comprised of
phospholipids, water, and high concentrations of ethanol that allow medications to reach deep
into the epidermal layers or the systemic circulation. This review article provides an overview
of the composition, preparation method, evaluation, and applications of ethosomes as well as
their structure, benefits, and drawbacks.
