| 1 |
Author(s):
Abhay Shripad Joshi, Dr. S. S.Angadi, Dr. Gajanan A.Vaishnav, Dr. Yuvraj R. Girbane, Renuka B. Dhakne.
Page No : 1-5
|
Comparative study of pharmacokinetic behavior of Erythromycin in rats using LC MS/MS
Abstract
In an open randomized crossover study, the pharmacokinetic of erythromycin were compaired with Neostigmine,Atropine,Metoclopramide and omeprazole after a single dose in 12 Wistar rats for oral and IV pharmacokinetic study.Erythromycin was administered at a dose of 50 mg/kg while other drugs Neostigmine (40 µg/kg),Atropine (10 mg/kg),Metoclopramide (12.5 mg/kg) and omeprazole (50 mg/kg) were given and oral pharmacokinetic and IV pharmacokinetic was studied. Erythromycin in combination with Omeprazole shown significant increase in Cmax (2.76 ±0.15) and AUC (7.29 ± 0.554) when given orally as compare to control group.Whereas Erythromycin in combination with Neostigmine (1.24 ± 0.755),Atropine(0.56 ± 0.085),Metoclopramide(1.06 ± 0.25) were shown less significant results.
In the present study the effect of erythromycin on pharmacokinetic parameters was performed.
| 2 |
Author(s):
Renuka B. Dhakne, Reshma Patil, Dr. S.S.Angadi, D.M.Kulkarni.
Page No : 6-11
|
Commercialization of innovative Pharmaceutical products-practical aspects and problems: an overview
Abstract
The process of turning an idea into a marketable product, service, or method is known as commercialization. The most dangerous and costly stage of the technology implementation and product life cycle is commercialization. Commercialization involves testing many ideas and selecting the products that are safer, more effective, and more efficacious than the existing product. Careful justification of practical implementation is very important otherwise problems may occur. Problems in commercialization are usually based on some practical aspects. Problems can also arise in technology selection and strategic planning of technology implementation. This review article briefly discusses the problems in commercialization and gives some ideas on the points to be considered in successful commercialization
| 3 |
Author(s):
Gajanan Vaishnav, Sushama Vaishnav, Yuvraj Girbane, Abhay Joshi.
Page No : 12-14
|
Rapid microtiter plate based assay protocol for herbal extracts
Abstract
DPPH assay has been practiced by researchers across the world for estimation of antioxidant activity. The reagents are costly and hazardous to environment. We describe a rapid and fast microplate based protocol for DPPH assay of herbal extracts.
| 4 |
Author(s):
Sushama Vaishnav, Gajanan Vaishnav, Abhay Joshi, Yuvraj Girbane.
Page No : 15-20
|
Preparation and in-vitro assessment of Tolbutamide nanosponges
Abstract
In this research, we have used polyethylene to characterise and produce Nanosponges tolbutamide oral formulations (poly-caprolactone). For decades, efficient targeted pharmaceutical distribution technologies have been a pipe dream. Nanosponges drug delivery technology has emerged as one of the most promising new medication delivery methods. Nanosponges drug delivery technology has recently become a significant advancement in overcoming various biopharmaceutical challenges. Before it reaches the precise target surface, the Nanosponges target the medicine in the body's systemic circulation and begin to release the drug in a controlled and consistent way. A broad range of drug molecules have been filled with hydrophilic and lipophilic drug material in Nanosponges medicine release devices. As a result, the Nanosponges are a suitable target carrier molecule. The medicine may be given at a specific place in the Nanosponges approach, preventing the drug from destroying proteins and extending drug release in a predictable manner. According to the FTIR and DSC investigations, there was no significant association between the medication and the excipients. In nanoscale ranges, prepared nanoparticles having spherical shape have been found to be resilient. The rubber's surface, which has an explosive effect and indicates that action is about to begin, exposes free material particles. Drug release studies indicate that drugs will continue to be released into the polymeric matrix. The tolbutamide-loaded nano-carrying unit was absorbed with continuous drug release patterns in this study, demonstrating the effectiveness of increased solubility.
| 5 |
Author(s):
Kulkarni Dipali Manik, R.B.Dhakne , R.R.Patil.
Page No : 21-26
|
Review of Nyctanthes arbortristis as a medicinal plant
Abstract
Ayurveda is one of the oldest systems of medicine that uses plants and their extracts for treatment and management of various diseased states. Each part of the plant has some important medicinal value and is thus commercially exploitable. It is now considered as a valuable source of several unique products for the medicines against various diseases and also for the development of some industrial products. The present study is to focus on the potential phyto-chemicals and pharmacological activity of plant N. arbor - tristis. In view of this, the study was designed to investigate for chemical constituents, anti-cancer and anti-inflammatory activities of solvent leaf extracts. Phytochemical screening revealed the presence of alkaloid, steroids etc. The extract exhibited significant anti-cancer and anti inflammatory properties and the observed biological activities in this study provide scientific validation of ethnomedicinal use of this plant.
