Author(s) :

Onkar G. Bodkhe , Ajay J. Malode.

Volume/Issue :

Abstract :

In the late Nineteen century, rapidly disintegrating drug delivery systems were developed as an alternative to capsules, tablets, and syrups for geriatric and pediatric patients with dysphagia. To meet these needs, many orally disintegrating tablets have been commercialized that disintegrate in the mouth within a minute without chewing or drinking water. Oral drug delivery technology has since been upgraded from conventional dosage forms to modified-release dosage forms, and more recently, rapidly disintegrating films have been developed instead of orally disintegrating tablets. Orally dissolving fast-dissolving films (OFDFs) have recently entered the market because they are more convenient and easier to use compared to other dosage forms such as orally disintegrating tablets. The technology has evolved in recent years from the confectionery and oral care market in the form of breath strips to become a novel form that is widely accepted by consumers, attracting a large number of pharmaceutical industry interest in his OFDF. A rapidly dissolving film in the mouth is a type of drug delivery system that disintegrates or dissolves within seconds without absorbing water when placed in the oral cavity. OFDF is very similar in shape, size and thickness to a postage stamp. These films have the ability to deliver drugs systemically via intragastric, sublingual, or buccal routes of administration and are also used for topical effect. This type of technology provides a convenient way to administer medications to the general population as well as special populations such as children, the elderly, bedridden patients, and psychiatric patients. Some companies have introduced a more robust form of fast-dissolving drug delivery that places a film on or under the tongue. When this film is applied to the tongue, it immediately dissolves and releases the drug, which dissolves in saliva. Some drugs are absorbed through the mouth, throat, and esophagus when saliva enters the stomach. In such cases, the bioavailability of the drug is improved, the risk of choking is eliminated, and the mouthfeel is improved. The current review describes various formulation considerations, manufacturing processes, and quality control of OFDF.

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